Cialis is one of the most common drugs with the active ingredient tadalafil, used as the primary drug for erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). The long-acting character is a unique feature of Cialis, but several factors come into play regarding its duration.
The Pharmacological Basis: Mechanism of Tadalafil
The mechanism through which tadalafil acts inhibits the effect of the enzyme phosphodiesterase type 5. This enzyme hydrolyzes cGMP, which is a crucial factor for the relaxation of the smooth muscles incorporated in a blood supply to the penis during erection. By blocking this conversion of cGMP, tadalafil raises the levels of cGMP in the blood and, when sexual arousal occurs, causes increased blood supply in the penis so that erection occurs. Such a mechanism explains the prolonged timeframe attributed to Cialis.
“36-Hour Window”: A Myth or Reality?
Creatively marketed with a “36-hour window” of efficacy for the treatment of ED, Cialis Tablet warrants further analysis of the meaning inherent in this phrase. Technically, this statement is true but may not confer a good perception. It does not conclude that there would be an erection for 36 hours. It means that the possibility of having an erection exists through stimulation within that time frame.
A peak concentration of tadalafil in the blood occurs from 30 minutes to 6 hours from ingestion, while effects can last up to 36 hours, meaning that the drug is active in your system and facilitates an erection whenever needed during that time.
The Individual Differences: Factors Affecting Duration
Several factors come into play in this regard:
- Dosage:
Cialis is available in doses ranging from 2.5 to 20 mg, while higher doses provide more prolonged performance.
- Metabolism:
Those with different metabolic rates will process tadalafil at different reaction speeds. So, the fast metabolism offers fast action.
- Medical Condition:
Medical conditions that involve liver or kidney function tend to hold back the quick procession of tadalafil in the body and its effect.
- Food and Alcohol:
Generally, food occupies a small percentage when it comes to absorption of tadalafil. The presence of excessive amounts of alcohol would work against its effectiveness and increase side effects.
- Other Medications:
Any possible interactions with other medications, particularly nitrates, may be dangerous and should be discussed with a physician.
Beyond ED: Cialis Tablet Use in BPH
Cialis also finds its place in the treatment for benign prostatic hyperplasia, which is an enlarged prostate condition. A lower dose (2.5 or 5mg) is usually taken daily in this condition. The idea is to have consistent amounts of tadalafil in the body to relieve BPH symptoms, as opposed to trying to obtain an erection on demand. It is why, in the use against BPH, the 36-hour window becomes less valid. The lower daily dose allows for a steady state of the drug.
Conclusion
A firm acquaintance with the issues relating to factors that determine the working duration of Cialis will help you attain maximum benefits safely and proficiently. Never self-medicate or try to modify the prescribed dose without medical guidance.